Formula optimization and physical stability evaluation of effervescent tablet preparations of aqueous extract of Moringa leaves (Moringa oleifera L.)

Authors

  • Benazir Evita Rukaya Politeknik Kaltara
  • Syuhada Syuhada Politeknik Kaltara
  • Devy Yulia Veronika Politeknik Kaltara

DOI:

https://doi.org/10.57174/jborn.v2i3.62

Keywords:

effervescent, moringa, physical stability, tablets

Abstract

Moringa leaves (Moringa oleifera L.) are a plant that is widely consumed by Indonesian people and has high nutrition and antioxidants. Utilization of Moringa leaves as a health supplement requires an innovative dosage form to make it practical to use, one of which is by making it in the form of effervescent tablets. The purpose of this study was to obtain an optimal formula for effervescent tablets of aqueous extract of Moringa leaves (Moringa oleifera L.). This study was an experimental study, by preparing effervescent tablets of aqueous extract of Moringa leaves using 3 different formulas using the wet granulation method. The physical stability of the effervescent tablets obtained was then evaluated. The evaluation results were analyzed to obtain the optimal formula from the 3 formulas. The research results obtained showed that F3 was a formula that had good physical stability of granules and tablets. Granules from F3 have an angle of repose of 22.45°, and a compressibility percentage of 12.67%. F3 effervescent tablets have a weight uniformity that does not exceed 5% or 10%, size uniformity that is not more than 3 times the thickness of the tablet, and a faster dissolving time compared to other formulas, namely 1 minute 22 seconds. Based on these results, it can be concluded that the optimal formula of the 3 formulas is F3 with an acid and base concentration of 20% each.

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References

Husni P, Pratiwi AN, Baitariza A. Formulası Krım Ekstrak Etanol Daun Kelor (Moringa oleifera Lamk). J Ilm Farm Farmasyifa. 2019;2(2):101–10.

Maryam S, Baits M, Nadia A. Pengukuran Aktıvıtas Antıoksıdan Ekstrak Etanol Daun Kelor (Moringa oleifera Lam.) Menggunakan Metode Frap (Ferric Reducing Antioxidant Power). J Fitofarmaka Indones. 2016;2(2):115–8.

Ni Nyoman Yuliani DPD. Uji aktivitas antioksidan infusa daun kelor dengan metode 1,1- diphenyl-2-picrylhydrazyl (DPPH). J Kesehat. 2015;14:1–5.

Aminah S, Ramdhan T, Yanis M. Syarifah Am inah et. al. : Kandungan Nut risi dan Sifat Fungsional Tanam an Kelor ( M oringa oleifera ). Bul Pertan Perkota. 2015;5(30):35–44.

Thamrin A, Lestari RS, Hartono R. Formulasi Pembuatan Makanan Tambahan Untuk Balita Gizi Kurang. Media Gizi Pangan. 2013;XV(1):1–6.

Sari ND. Pembuatan minuman fungsional tablet effervescentdari bubuk ekstrak daun kacang tujuh jurai (Phaseolus lunatus, L.). J Litbang Ind. 2019;23–31.

Mukhtarini. “Ekstraksi, pemisahan senyawa, dan identifikasi senyawa aktif.” J Pharm. 2014;V:361.

Chabib L, Indrati O, Rizki MI. Formulasi Tablet Effervescent Ekstrak Lidah Buaya (Aloe vera). J Pharmascience. 2015;2(1):72–80.

M. Dafit Mulyadi, Ika Yuni Astuti BAD. Formulası Granul Instan Jus Kelopak Bunga Rosela (Hibiscus sabdariffa L) Dengan Varıası Konsentrası Povıdon Sebagaı Bahan Pengıkat Serta Kontrol Kualıtasnya. Pharmacy. 2011;08(03):29–41.

Apsari PA, Sari DNE, Kusuma AP, Indrati O. Effervescent Tablet Formulation Melinjo Seed Extract (Gnetum gnemon L.) Using PEG 6000 As Lubricant and Citric Acid - Tartaric Acids As Acid Sources. J Eksakta. 2018;18(1):30–41.

Aulton. Pharmaceutics The Science Dosage Form Design. Dalam: 2nd ed. 2nd ed. New York; 2002.

Anam C, Kawiji, Setiawan RD. Kajian Karakteristik Fisik Dan Sensori Serta Aktivitas Antioksidan Dari Granul Effervescent Buah Beet (Beta Vulgaris) Dengan Perbedaan Metode Granulasi Dan Kombinasi Sumber Asam. J Teknosains Pangan Vol. 2013;2(2):21–8.

Ulfa AM. Analısa Ujı Kekerasan, Kerapuhan Dan Waktu Hancur Asam Mefenamat Kaplet Salut Generık Dan Merek Dagang. 2018;1(2):59–68.

Serevino L. Ambuk ABSL. Formulası Tablet Effervescent Ekstrak Daun Sıngkong (Manihot utillissima Pohl.) Dan Ekstrak Herba Pegagan (Centella asiatica (L.) Urban) Serevino. Skripsi. 2015;1.

Cessa Lynatra, Wardiyah YE. Formulation of Effervescent Tablet of Temulawak. J Teknol Dan Seni Kesehat. 2018;09:72–82.

Dewi R, Iskandarsyah I, Octarina D. Tablet Effervescent Ekstrak Belimbing Wuluh (Averrhoa bilimbi L.) dengan variasi Kadar Pemanis Aspartam. Pharm Sci Res. 2014;1(2):116–33.

Ainurofiq A, Azizah N. Perbandingan Penggunaan Bahan Penghancur Secara Intragranular, Ekstragranular, Dan Kombinasinya. J Pharm Sci Clin Res. 2016;01(01):1–9.

Tanjung YP, Puspitasari I. Formulasi Dan Evaluasi Fisik Tablet Effervescent Ekstrak Buah Mengkudu (Morinda Citrifolia L.). Farmaka. 2019;17(1):1–14.

Herlinawati L. Mempelajarı Pengaruh Konsentrası Maltodekstrın Dan Polıvınıl Pırolıdon (PVP) Terhadap Karakterıstık Sıfat Fısık Tablet Effervescent Kopı Robusta (Coffea robusta Lindl). J Agribisnis Dan Teknol Pangan. 2020;1(1):1–25.

Anova IT, Kamsina K, Hermianti W. Formulasi Perbandingan Asam Basa Serbuk Effervescent dari Coklat Bubuk. J Litbang Ind. 2016;6(2):99.

Oktami E, Lestari F, Aprilia H. Studi Lietratur Uji Stabilitas Sediaan Farmasi Bahan Alam.Prosiding Farmasi. 2021;7(1):72-77

Published

30-11-2022

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