Vol. 3 No. 2 (2023): Volume 3 Issue 2 tahun 2023
● Articles: 7
● Editorial in chief: apt. Syuhada, M.Farm.
● Managing Editorial: apt. Benazir Evita Rukaya, M.Farm.
Articles
-
Identification Of Alkaloids From the Ethanol Extract of Strychnos ligustrina Using Liquid Chromatography-Mass Spectrometry (LC-MS)
Abstract: 577
| 
PDF 64-71 (Indonesian): 720
Abstract
Bidara Laut (S. ligustrina) stem bark is commonly used by the society of West Nusa Tenggara and Bali as an antimalaria treatment. The study aims to quantify the number of chemical components from the alkaloid family present in the ethanolic extract of S. ligustrina bark. With a 70% ethanol-based solvent, the bark of S. ligustrina was extracted using the maceration process. LC-MS was used to assess the number of alkaloids present in the bark of S. ligustrina. In a reverse phase column using acetonitrile and formic acid as the mobile phases, gradient elution was carried out for 16 minutes. Five alkaloid compounds were discovered as a consequence of the investigation, including the 3-iso-ajmalicine molecule, which had an m/z of 353.1847 and a retention time of 4.26 minutes, and the brucine compound, which had an m/z of 395.1953 and a retention time of 5.06 minutes. The other 3 molecules are confirmed with m/z of that molecules C24H28N2O4, C22H24N2O3, and C11H17NO6 are 409.2107, 365.1848, and 260.1116, respectively, and their retention times are 4,90 minutes, 5,35 minutes, and 1,32 minutes. 3-iso-ajmalicine has just been confirmed to be present in S. ligustrina stem bark.
-
Analgesic Effect Test of Matoa Leaf Ethanol Extract (Pometia pinnata J.R. Forst & G. Forst) in Male White Mice (Mus musculus)
Abstract: 366
|
PDF 72-79 (Indonesian): 268
Abstract
Pain is a condition that indicates the body is experiencing tissue damage and inflammation. Pain can be managed with analgesics. One of the plants that is thought to have an analgesic effect is matoa leaf (Pometia pinnata J.R. Forst & G. Forst). This study was an experimental study using male white mice which were divided into 5 treatment groups, namely group I was given NaCMC as a negative control, group II was given ibuprofen as a positive control, and groups III, IV, and V were given EEDM with a successive dose of 200 mg /kgBB, 400 mg/kgBB, and 800 mg/kgBB. The test animals were induced with 1% acetic acid intraperitoneally after 30 minutes of oral administration of the test preparation. Observations were made by calculating the pain response marked by stretching for 180 minutes with an interval of 10 minutes. The research data were processed statistically using the One Way ANOVA test and the LSD follow-up test. The positive control group for the EEDM group at doses of 200 mg/kg, 400 mg/kg, and 800 mg/kg showed no significantly different results with a P>0,05. From the study results, it can be concluded that EEDM has an analgesic effect on male white mice with an effective dose of 800 mg/kgBB.
-
Antioxidant Test of Clitoria ternatea L. Ethanol Extract and Ointment Formulation on Healing of New Zealand White Rabbit Back Slashes
Abstract: 665
|
PDF 80-94 (Indonesian): 541
Abstract
Telang flower (Clitoria ternatea L.) has antioxidant effects because it contains compounds such as phenols, anthocyanins, flavonol glycosides, kaempferol glycosides, terpenoids, steroids, flavonoids, and tannins. This study aims to determine whether telang flower ethanol extract has antioxidant activity, whether telang flower ethanol extract ointment can heal cuts in rabbits and determine the effective concentration of telang flower ethanol extract ointment for healing cuts in rabbits. This study used telang flower extract macerated with 70% ethanol. The concentration of the extract was made as much as 3, namely 0.1%, 0.2%, 0.4%. The extract was tested for antioxidant activity using the DPPH method. The tested extract was then made into an ointment and applied to the rabbit's back, and wound healing was observed. Based on the results of statistical tests using SPSS®, variations in the concentration of the ethanol extract of the butterfly pea flower affected the antioxidant activity. The 0.2% concentration gave a significant difference compared to the 0.1% and 0.4% concentrations. Telang flower ethanol extract ointment can heal the incision wound on the rabbit's back. Based on the results of statistical tests using SPSS® on the healing of cuts in rabbits showed a significant difference. The 0.2% concentration differed significantly from the 0.4% concentration, where the time required for the 0.2% concentration was faster than the 0.4% concentration.
-
Combination of Gotu Kola (Centella asiatica (L.)) Ethyl Acetate Extract and Virgin Coconut Oil (VCO) as Burn Healing
Abstract: 403
|
PDF 95-105: 237
Abstract
Burns result from exposure to heat sources like fire, chemicals, or radiation and can lead to tissue loss or damage. Traditional healing of burns often involves using herbal remedies like gotu kola and coconut, typically oil extracts. This study aims to identify the healing effects of burns by administering a combination of ethyl acetate extract of gotu kola herb and virgin coconut oil (VCO) to mice. The mice were divided into 7 groups, namely negative control (K(-)) was given tween 20; positive control (K(+)): burn topical medicine on the market, P1: 10% Ethylacetate extract in tween 20; P2: VCO; P3: Ethyl acetate extract 10% and VCO 50% in tween 20; P4: 5% Ethyl acetate extract in VCO; P5: extract 10% Ethyl acetate in VCO and treated for 21 consecutive days with a frequency of twice a day. The results showed that the combination of 10% ethyl acetate extract of gotu kola herb in VCO exhibited the highest healing activity for burns, comparable to the positive control (K(+)) topical medicine on the market. The higher the extract concentration and VCO, the better the healing activity of burns.
-
Evaluating Drug Use for Coronary Heart Disease Patients After Stent Insertion at RSPAD Gatot Soebroto
Abstract: 330
|
PDF 106-117 (Indonesian): 750
Abstract
Coronary Heart Disease (CHD) occurs when the coronary arteries are narrowed by a buildup of atheroma and fatty material in the walls. Stent placement is done to treat narrowed coronary arteries and an option if the patient has tried medication or lifestyle changes but fails to improve heart health and has blockages in the arteries. This study aims to evaluate the 4 medication usage accuracies, to determine the characteristics and medication usage profiles in CHD patients after stent placement at Gatot Soebroto Hospital. This research was conducted with analytical descriptive and retrospective data collection through medical records for the 2021 period. The sample used was 83 patients. The study resulted based on the characteristics the most patients with CHD after stent placement were aged <65 years with 57 patients (68.68%), and the most comorbid hypertension was 26 patients (31.32%). The medicine widely used in CHD patients after stent placement is a combination of aspirin and clopidogrel in as many as 70 patients (83.34%). The parameters of the medication usage accuracy, the right indication, the right medicine, the right dose, and the right patient resulted in 100% that the patient got the suitability for medication use. The results of the relationship between variables and medication use through SPSS showed that gender had a sig value of 0.051 (>0.005), age had 0.544 (>0.005), and risk factors had 0.167 (>0.005) means that there is no relationship in medication use.
-
Evaluation of Drug Management at the Tampang Tumbang Anjir Health Center, Kuala Kurun, Gunung Mas Regency, Central Kalimantan, 2022
Abstract: 318
|
PDF 118-129 (Indonesian): 220
Abstract
Management and storage of drugs is a very important aspect. Therefore, the management and storage of drugs need to be carried out as well as possible to prevent drug damage. This writing aims to evaluate the drug administration information data at the Tampang Tumbang Anjir Health Center, Tampang Tumbang Anjir District, Gunung Mas Regency, Central Kalimantan. This study uses a non-experimental observational method which has a quantitative descriptive nature. The data in this study were taken concurrently from prescription sheets, stock cards, labeling, and waiting times for prescription services. This study obtained the results of the percentage value of damaged or expired goods (18.09%), 1-month availability (1.3 months), number of drug items per prescription (0.37%), the average speed of non-concoction prescription service (1.52 minutes), the average speed of concoction prescription service (1.01 minutes), and the percentage of drug labeling (0%). So it can be concluded that the management of drugs at the Tampang Tumbang Anjir Public Health Center, Gunung Mas Regency, Central Kalimantan is not good because there are still some that do not meet the applicable regulatory standards, namely the National Formulary (FORNAS) and DOEN.
-
The Effect of the Healthy Living Education Program on Weight Loss and Abdominal Circumference in Nursing Students
Abstract: 223
|
PDF 130-138 (Indonesian): 179
Abstract
Obesity and abdomen circumference are risk factors for non-communicable diseases. These signs are commonly seen in productive age groups, specifically students. A healthy way of life is essential for avoiding extra weight and abdominal girth. The purpose of this study is to examine the impact of healthy living on weight loss and abdominal circumference. A quasi-experiment with no control was used as the study approach. Body weight and abdomen circumference are the dependent variables, and health education is the independent variable. The target population comprises 93 students enrolled in the D3 Nursing study program. Purposive sampling was utilized in this study. Students are the inclusion criteria. Students who have a weight above their normal using an ideal body weight indicator and are willing to participate in the program for 7 days complete the inclusion requirements. While the exclusive criteria are students with a history of hypertension or diabetes mellitus, they also include students who feel ill when their weight and abdomen circumference are measured. There were 28 people who responded. Respondents reflect on their healthy lifestyle activities for seven days. Following the pre-test and post-test, the two data sets were processed and the data normality test was performed, yielding normal distribution data. A paired t-test was performed as a result of this. Results. The difference in weight before and after the education program had a p-value of 0.000, whereas the difference in abdominal circumference had a pvalue of 0.000. Limiting the amount of high carbohydrates and fats in diet as well as doing physical activity can reduce body fat formation and thus have an impact on weight loss. Conclusion. The healthy living program influences body weight and abdomen level
