Vol. 4 No. 3 (2024): Volume 4 Issue 3 tahun 2024
● Articles: 5
● Editorial in chief: apt. Syuhada, M.Farm.
● Managing Editorial: apt. Benazir Evita Rukaya, M.Farm.
Pharmacy
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Toxicity Study of Pacing Rhizome Infusion (Costus speciosus) Using the Brine Shrimp Lethality Test (BSLT) Method
Abstract: 202
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PDF 81-89 (Indonesian): 68
Abstract
Costus speciosus or Pacing, is a herbal plant that has long been used in traditional medicine in various Asian countries. This plant is reported to have biological activities such as antidiabetic, anti-inflammatory, and anticancer. However, information regarding its toxicity is still limited. This study aims to determine the toxicity of Costus speciosus rhizome infusion using the Brine Shrimp Lethality Test (BSLT) method. This method utilizes Artemia salina Leach larvae as a model organism to assess potential toxicity. Pacing rhizomes contain bioactive compounds such as flavonoids, saponins, and alkaloids with pharmacological potential. The results showed that pacing rhizome infusion has very high toxicity based on the Clarkson toxicity category with an LC50 value of 54.99 ppm. These findings provide a basis for further research on the safety and pharmacological applications of pacing rhizomes as herbal medicine ingredients.
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Cold Powder Formulation Based on Moringa Leaf Powder (Moringa oleifera powder) with Organoleptic and PH Tests as Stability Parameters of the Preparation
Abstract: 262
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PDF 90-100 (Indonesian): 173
Abstract
Cooling powder is a traditional skincare product widely used for its benefits in moisturizing, brightening, and soothing the skin. This study aims to formulate a cooling powder based on Moringa oleifera powder and evaluate its stability through organoleptic and pH tests during storage. The research methodology involves formulating a cooling powder using key ingredients, including Moringa powder, yam powder, rice powder, corn powder, and yam juice. The organoleptic evaluation covers color, aroma, texture, and homogeneity, while pH measurement is conducted to ensure product stability. Additionally, a hedonic test was conducted using a repeated measures design method with 10 panelists selected through purposive sampling. The results indicate that the Moringa-based cooling powder exhibits good physical stability over a seven-day storage period at room temperature, with no significant changes in organoleptic parameters and a stable pH value of 5. The hedonic test results indicate that the product was well-received by panelists, with a preference level comparable to that of commercial products. In conclusion, Moringa-based cooling powder has the potential to be a stable and safe natural skincare product.
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Overview of Quality of Life of Diabetic Neuropathy Patients at Tarakan Naval Hospital
Abstract: 227
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101-111 (Indonesian): 77
Abstract
Diabetic neuropathy is one of the chronic complications of diabetes mellitus that can affect the quality of life of patients. This study aims to evaluate the quality of life of patients with diabetic neuropathy, focusing on key aspects such as physical activity, psychological well-being, sleep quality, and treatment satisfaction. This study employed a quantitative approach using a survey method with diabetic neuropathy patients undergoing treatment at Tarakan Navy Hospital. Data were collected through a questionnaire that measured various aspects of patient quality of life. The results showed that most patients had a good quality of life, with an average score above 75%. Disturbances to daily physical activities scored 92.50%, while heavy activities were 88.33%. The psychological aspect revealed that the patient's enthusiasm level reached 100%, with a perception of physical health at 88.33% and awareness of complications at 93.33%. Sleep quality remained quite good, with a score of 95.00%, and no major depression was detected (100%). Satisfaction with treatment reached the highest score, with therapeutic effectiveness of 98.33% and patient satisfaction of 100%. These findings show that with proper management, diabetic neuropathy patients can still live a good quality of life.
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Drug Prescrıptıon Overvıew for Dıabetes Mellıtus Patıents at Karang Rejo Communıty Health Center Tarakan Perıod Aprıl-June 2024
Abstract: 167
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PDF 112-119 (Indonesian): 65
Abstract
Diabetes mellitus requires pharmacological therapy to control blood glucose levels and prevent complications. Evaluating drug prescribing patterns in Community Health Centers is crucial for assessing the suitability of therapy by clinical guidelines. Puskesmas is the primary healthcare facility that is easily accessible to the community, especially for common and chronic diseases, one of which is Diabetes mellitus. This study analyzed drug prescribing patterns in patients with diabetes mellitus at the Karang Rejo Community Health Center, Tarakan, including the number of drug items per prescription, the most frequently prescribed types of drugs, and the distribution of prescriptions based on pharmacological groups. This study employed a retrospective descriptive design with a total sampling method, utilizing medical record data from patients with diabetes mellitus. The analysis was carried out descriptively quantitatively using frequency and percentage distributions. The results showed that most patients were female (66%) with an average age of 57.89 years and a body weight of 60.69 kg. The average number of drug items per prescription was 3.29, with oral antidiabetics as the most frequently prescribed drug group (36.28%), followed by antihypertensives (16.45%) and neurotropic vitamins (13.28%). In addition, 15.07% of prescriptions contained ≥5 types of drugs, indicating polypharmacy that needs to be monitored to prevent drug interactions and side effects. The pattern of drug prescription at Karang Rejo Health Center is based on the therapeutic needs of patients with diabetes mellitus. However, routine monitoring is still needed to ensure the effectiveness and safety of therapy, especially for patients with polypharmacy.
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Atopic Dermatitis Treatment Satisfaction Level Evaluation based on Consumer Reviews from WEBMD
Abstract: 216
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PDF 120-128 (Indonesian): 94
Abstract
This study evaluated factors that influence user satisfaction with Atopic Dermatitis (AD) treatment based on consumer reviews from WebMD. Data were obtained from a public dataset on the Zenodo.org website, including user ratings of ease of use, effectiveness, price, and satisfaction of AD drugs. Descriptive analysis was performed using the GraphPad® and Microsoft Excel® applications. The results showed that effectiveness and ease of use played a greater role in user satisfaction than price. Drugs with the highest satisfaction, such as Diflorasone and Amcinonide, were considered very effective despite their relatively high prices. Conversely, drugs with lower satisfaction, such as Hydrocortisone Probutate, showed that high prices do not always guarantee effectiveness. Therefore, the selection of therapy should consider effectiveness and convenience of use.
